Tacrolimus Assay Comparison: Analytical and Operational Considerations for Immunoassay vs Mass Spectrometry Testing in a High Volume Clinical Laboratory
The Journal of Applied Laboratory Medicine, jfaf199, https://doi.org/10.1093/jalm/jfaf199
Published: 07 January 2026
INTRODUCTION
Tacrolimus is an immunosuppressant drug primarily used for prevention of organ rejection following transplantation (1). Tacrolimus’ main activity is the inhibition of T-cell activation through its interaction with calcium-dependent calcineurin (2, 3). Tacrolimus has a narrow therapeutic index, erratic absorption, and large interpatient variation in the pharmacokinetics…https://academic.oup.com/jalm/advance-article/doi/10.1093/jalm/jfaf199/8416546?utm_source=authortollfreelink&utm_campaign=jalm&utm_medium=email